Desorden linfoproliferativo T sistémico de la infancia asociado al virus Epstein-Barr: reporte de un caso
Palabras clave:
desorden linfoproliferativo T sistémico de la infancia asociado al virus Epstein-Barr, síndrome hemofagocítico, linfocitos T, virus Epstein-Barr.
Resumen
El desorden linfoproliferativo T sistémico de la infancia asociado al virus Epstein-Barr es una entidad clínica de descripción reciente, potencialmente mortal en niños y en adultos jóvenes. Se caracteriza por una proliferación clonal de linfocitos T con un fenotipo citotóxico activado infectados por el virus. Es más frecuente en países de Asia y México, y se desconoce su incidencia en el medio. Se reporta un caso de esta enfermedad, con progresión indolente y desenlace fatal.
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Referencias bibliográficas
1. Quintanilla-Martinez L, Kimura H, Jaffe ES. EBV-positive T-cell lymphoproliferative disorders of childhood. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (ed 4th). Lyon: IARC; 2008.
2. Quintanilla-Martinez L, Kumar S, Fend F, Reyes E, Teruya-Feldstein J, Kingma DW, et al. Fulminant EBV(+) T-cell lymphoproliferative disorder following acute/chronic EBV infection: a distinct clinicopathologic syndrome. Blood 2000; 96: 443-451.
https://doi.org/10.1182/blood.V96.2.443
3. Cohen JI, Kimura H, Nakamura S, Ko YH, Jaffe ES. Epstein-Barr virus-associated lymphoproliferative disease in non-immunocompromised hosts: a status report and summary of an international meeting, 8-9 September 2008. Ann Oncol 2009; 20: 1472-1482.
https://doi.org/10.1093/annonc/mdp064
4. Ohshima K, Kimura H, Yoshino T, Kim CW, Ko YH, Lee SS, et al. Proposed categorization of pathological states of EBV-associated T/natural killer-cell lymphoproliferative disorder (LPD) in children and young adults: overlap with chronic active EBV infection and infantile fulminant EBV T-LPD. Pathol Int 2008; 58: 209-217.
https://doi.org/10.1111/j.1440-1827.2008.02213.x
5. Kasahara Y, Yachie A, Takei K, Kanegane C, Okada K, Ohta K, et al. Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection. Blood 2001; 98: 1882-1888.
https://doi.org/10.1182/blood.V98.6.1882
6. Rodriguez-Pinilla SM, Barrionuevo C, Garcia J, de los Angeles M, Pajares R, Casavilca S, et al. Epstein-Barr virus-positive systemic NK/T-cell lymphomas in children: report of six cases. Histopathology 2011; 59: 1183-1193.
https://doi.org/10.1111/j.1365-2559.2011.04047.x
7. Chuang HC, Lay JD, Chuang SE, Hsieh WC, Chang Y, Su IJ. Epstein-Barr virus (EBV) latent membrane protein-1 down-regulates tumor necrosis factor-alpha (TNF-alpha) receptor-1 and confers resistance to TNF-alpha-induced apoptosis in T cells: implication for the progression to T-cell lymphoma in EBV-associated hemophagocytic syndrome. Am J Pathol 2007; 170: 1607-1617.
https://doi.org/10.2353/ajpath.2007.061026
8. Kimura H, Morishima T, Kanegane H, Ohga S, Hoshino Y, Maeda A, et al. Prognostic factors for chronic active Epstein-Barr virus infection. J Infect Dis 2003; 187: 527-533.
https://doi.org/10.1086/367988
9. Kimura H, Ito Y, Kawabe S, Gotoh K, Takahashi Y, Kojima S, et al. EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases. Blood 2012; 119: 673-686.
https://doi.org/10.1182/blood-2011-10-381921
10. Cohen JI, Jaffe ES, Dale JK, Pittaluga S, Heslop HE, Rooney CM, et al. Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States. Blood 2011; 117: 5835-5849.
https://doi.org/10.1182/blood-2010-11-316745
2. Quintanilla-Martinez L, Kumar S, Fend F, Reyes E, Teruya-Feldstein J, Kingma DW, et al. Fulminant EBV(+) T-cell lymphoproliferative disorder following acute/chronic EBV infection: a distinct clinicopathologic syndrome. Blood 2000; 96: 443-451.
https://doi.org/10.1182/blood.V96.2.443
3. Cohen JI, Kimura H, Nakamura S, Ko YH, Jaffe ES. Epstein-Barr virus-associated lymphoproliferative disease in non-immunocompromised hosts: a status report and summary of an international meeting, 8-9 September 2008. Ann Oncol 2009; 20: 1472-1482.
https://doi.org/10.1093/annonc/mdp064
4. Ohshima K, Kimura H, Yoshino T, Kim CW, Ko YH, Lee SS, et al. Proposed categorization of pathological states of EBV-associated T/natural killer-cell lymphoproliferative disorder (LPD) in children and young adults: overlap with chronic active EBV infection and infantile fulminant EBV T-LPD. Pathol Int 2008; 58: 209-217.
https://doi.org/10.1111/j.1440-1827.2008.02213.x
5. Kasahara Y, Yachie A, Takei K, Kanegane C, Okada K, Ohta K, et al. Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection. Blood 2001; 98: 1882-1888.
https://doi.org/10.1182/blood.V98.6.1882
6. Rodriguez-Pinilla SM, Barrionuevo C, Garcia J, de los Angeles M, Pajares R, Casavilca S, et al. Epstein-Barr virus-positive systemic NK/T-cell lymphomas in children: report of six cases. Histopathology 2011; 59: 1183-1193.
https://doi.org/10.1111/j.1365-2559.2011.04047.x
7. Chuang HC, Lay JD, Chuang SE, Hsieh WC, Chang Y, Su IJ. Epstein-Barr virus (EBV) latent membrane protein-1 down-regulates tumor necrosis factor-alpha (TNF-alpha) receptor-1 and confers resistance to TNF-alpha-induced apoptosis in T cells: implication for the progression to T-cell lymphoma in EBV-associated hemophagocytic syndrome. Am J Pathol 2007; 170: 1607-1617.
https://doi.org/10.2353/ajpath.2007.061026
8. Kimura H, Morishima T, Kanegane H, Ohga S, Hoshino Y, Maeda A, et al. Prognostic factors for chronic active Epstein-Barr virus infection. J Infect Dis 2003; 187: 527-533.
https://doi.org/10.1086/367988
9. Kimura H, Ito Y, Kawabe S, Gotoh K, Takahashi Y, Kojima S, et al. EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases. Blood 2012; 119: 673-686.
https://doi.org/10.1182/blood-2011-10-381921
10. Cohen JI, Jaffe ES, Dale JK, Pittaluga S, Heslop HE, Rooney CM, et al. Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States. Blood 2011; 117: 5835-5849.
https://doi.org/10.1182/blood-2010-11-316745
Cómo citar
1.
Santiago Pacheco V, Lozano Bohórquez DM, Patiño Giraldo S, Gaviria Jaramillo LM, Rendón Henao J. Desorden linfoproliferativo T sistémico de la infancia asociado al virus Epstein-Barr: reporte de un caso. Med. Lab. [Internet]. 1 de julio de 2012 [citado 29 de noviembre de 2023];18(7-8):365-72. Disponible en: https://medicinaylaboratorio.com/index.php/myl/article/view/295
