Utilidad clínica de la medición de la hormona antimülleriana en niños

  • Juan D. Lasprilla-Tovar Universidad de Antioquia
  • Carolina Henao-Ochoa Universidad de Antioquia
  • Juan M. Alfaro-Velásquez Universidad de Antioquia
  • Germán Campuzano-Maya
Palabras clave: hormona antimülleriana, masculino, células de Sertoli, diferenciación sexual, trastornos testiculares del desarrollo sexual 46, XX, hipogonadismo, criptorquidismo, síndrome de Klinefelter.

Resumen

La hormona antimülleriana, inicialmente denominada sustancia inhibitoria mülleriana, es una glicoproteína homodimérica de 12,5 kDa, que pertenece a la familia del factor de crecimiento transformante beta (TGF-β) y desempeña un papel crucial en la diferenciación sexual masculina al favorecer la regresión de los conductos de Müller. Dado que su producción en el varón es principalmente por las células de Sertoli inmaduras, en las últimas décadas ha crecido su utilidad más allá de la evaluación de la función ovárica y tratamientos de fertilidad en las mujeres, lo que ha permitido evaluar en el varón la función testicular y los estados de hipogonadismo, trastornos de la diferenciación sexual, pubertad patológica, criptorquidia, entre otras condiciones clínicas revisadas en este manuscrito. Además, esta revisión describe el rol fisiológico de la hormona antimülleriana en los testículos prepuberales y las pruebas de laboratorio disponibles para su medición.

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Biografía del autor/a

Juan D. Lasprilla-Tovar, Universidad de Antioquia

Médico, especialista en Pediatría, residente de Endocrinología Pediátrica, Universidad de Antioquia. Medellín, Colombia.

Carolina Henao-Ochoa, Universidad de Antioquia

Médica, especialista en Pediatría, residente de Endocrinología Pediátrica, Universidad de Antioquia. Medellín, Colombia.

Juan M. Alfaro-Velásquez, Universidad de Antioquia

Médico, especialista en Pediatría y Endocrinología Pediátrica. Director Departamento de Endocrinología Pediátrica, Universidad de Antioquia. Medellín, Colombia.

Germán Campuzano-Maya

Médico, especialista en Hematología y Patología Clínica. Docente Ad Honorem, Facultad de Medicina, Universidad de Antioquia. Coordinador Grupo de Investigación en Patología Clínica. Médico Director, Laboratorio Clínico Hematológico. Medellín, Colombia.

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Cómo citar
1.
Lasprilla-Tovar JD, Henao-Ochoa C, Alfaro-Velásquez JM, Campuzano-Maya G. Utilidad clínica de la medición de la hormona antimülleriana en niños. Med. Lab. [Internet]. 1 de julio de 2017 [citado 17 de octubre de 2021];23(7-8):311-30. Disponible en: https://medicinaylaboratorio.com/index.php/myl/article/view/29
Publicado
2017-07-01
Sección
La Clínica y el Laboratorio
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