Prueba de aliento con 13C-metacetina en el diagnóstico y manejo de las enfermedades hepáticas

  • Germán Campuzano-Maya Laboratorio Clínico Hematológico
Palabras clave: 13C-metacetina, pruebas de aliento con 13C, pruebas funcionales del hígado.

Resumen

Una prueba diagnóstica, incluidas las del laboratorio clínico, las de patología y las de radiología en sus múltiples aplicaciones, es de utilidad clínica cuando su desempeño analítico alcanza indicadores de precisión y exactitud ideales, es decir, lo más cercano al 100%, cuando se utiliza en el diagnóstico, clasificación y manejo de un grupo de enfermedades para las cuales se ha diseñado. En el caso de las enfermedades hepáticas, ninguna de estas pruebas, hasta el momento disponibles, logra este objetivo e incluso están lejos de alcanzarlo, aun cuando son críticas en el diagnóstico y manejo de estas enfermedades. Con el descubrimiento de que el estómago podía ser colonizado con una bacteria, hoy denominada Helicobacter pylori, y el desarrollo posterior de la prueba de aliento con urea marcada con carbono 13 (13C-urea), múltiples pruebas de aliento han sido desarrolladas con sustratos marcados con 13C, siendo la prueba de aliento 13C-metacetina la más representativa para determinar la función hepática por esta metodología. En este módulo se presenta la prueba de aliento con 13C-metacetina como una nueva alternativa, no invasiva, para el estudio de la función hepática en el diagnóstico y seguimiento de las enfermedades del hígado. Además, se presentan los fundamentos de la prueba, los métodos para realizarla, la interpretación de los resultados, las limitaciones y las indicaciones de la misma.

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Biografía del autor/a

Germán Campuzano-Maya, Laboratorio Clínico Hematológico

Médico especialista en Hematología y Patología Clínica. Docente Ad Honorem, Facultad de Medicina, Universidad de Antioquia. Médico Director, Laboratorio Clínico Hematológico. Medellín, Colombia.

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Cómo citar
1.
Campuzano-Maya G. Prueba de aliento con 13C-metacetina en el diagnóstico y manejo de las enfermedades hepáticas . Med. Lab. [Internet]. 1 de septiembre de 2015 [citado 18 de septiembre de 2020];21(9-10):413-30. Disponible en: https://medicinaylaboratorio.com/index.php/myl/article/view/138
Publicado
2015-09-01
Sección
La Clínica y el Laboratorio