Off-Pump vs On-Pump Coronary Artery Bypass Grafting (CABG): Comparative Outcomes

doi:10.36384/01232576.782

Medicinay Laboratorio

2025, Volume: 29, Issue:3-4 : 78-82 doi: 10.36384/01232576.782

Research Article

Off-Pump vs On-Pump Coronary Artery Bypass Grafting (CABG): Comparative Outcomes

Toro Montoya

Gallego Noreña

Microbiólogo y Bioanalista, Estudiante de Maestría. Grupo Reproducción, Grupo Centauro, Investigación Universitaria, Universidad de Antioquia. Medellín, Colombi

Médico especialista en Ginecología y Obstetricia. Ginecólogo y Mastólogo, Clínica Las Américas. Medellín, Colombi

DOI : 10.36384/01232576.782

Received

Nov. 10, 2025

Revised

Nov. 28, 2025

Accepted

Dec. 13, 2025

Published

Dec. 29, 2025

Abstract

Abstract Introduction: Coronary artery bypass grafting (CABG) remains the gold standard surgical treatment for multivessel coronary artery disease. Conventional on-pump CABG utilizes cardiopulmonary bypass (CPB), whereas off-pump CABG (OPCAB) avoids CPB and is performed on a beating heart. The comparative safety and efficacy of these techniques remain debated. Materials and Methods: A prospective comparative study was conducted among 120 patients undergoing elective CABG. Patients were divided into two groups: On-pump CABG (n=60) and Off-pump CABG (n=60). Perioperative variables, postoperative complications, mortality, ICU stay, hospital stay, and graft patency were evaluated. Statistical analysis was performed using chi-square test and independent t-test with p<0.05 considered significant.Results:Off-pump CABG demonstrated significantly lower incidence of postoperative atrial fibrillation, reduced blood transfusion requirement, shorter ICU stay, and decreased ventilation time. However, complete revascularization rate and long-term graft patency were slightly higher in on-pump CABG. No significant difference in 30-day mortality was observed. Conclusion:Off-pump CABG is associated with reduced perioperative morbidity and faster recovery, while on-pump CABG provides more complete revascularization. Surgical expertise and patient selection remain crucial in determining optimal approach.

Keywords

Off-pump CABG

On-pump CABG

Cardiopulmonary bypass

Coronary artery disease

Postoperative outcomes

Graft patency

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